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JoVE Journal
Immunology and Infection

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Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care
 

Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care

Article doi: 10.3791/52397
February 16th, 2015

Summary February 16th, 2015

The lymphodepletive and immunomodulatory effects of chemotherapy and radiation standard of care can be leveraged to enhance the antitumor efficacy of T cell immunotherapy. We outline a method for generating EGFRvIII-specific chimeric antigen receptor (CAR) T cells and administering them in the context of glioblastoma standard of care.

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