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JoVE Journal
Immunology and Infection

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JoVE Journal Immunology and Infection
Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care
In Vivo Imaging Systems (IVIS) Detection of a Neuro-Invasive Encephalitic Virus
Journal (Immunology and Infection)
In Vivo Imaging Systems (IVIS) Detection of a Neuro-Invasive Encephalitic Virus
Clinical Application of Sleeping Beauty and Artificial Antigen Presenting Cells to Genetically Modify T Cells from Peripheral and Umbilical Cord Blood
Journal (Immunology and Infection)
Clinical Application of Sleeping Beauty and Artificial Antigen Presenting Cells to Genetically Modify T Cells from Peripheral and Umbilical Cord Blood
 

Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care

Article DOI: 10.3791/52397
February 16th, 2015 •
1,2, 1,3, 1, 1, 1,2,3, 1
1Duke Brain Tumor Immunotherapy Program, Department of Neurosurgery, Duke University, 2Department of Biomedical Engineering, Duke University, 3Department of Pathology, Duke University

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Summary
Automatic Translation
February 16th, 2015

The lymphodepletive and immunomodulatory effects of chemotherapy and radiation standard of care can be leveraged to enhance the antitumor efficacy of T cell immunotherapy. We outline a method for generating EGFRvIII-specific chimeric antigen receptor (CAR) T cells and administering them in the context of glioblastoma standard of care.

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