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Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care
Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care
JoVE Journal
Immunology and Infection
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JoVE Journal Immunology and Infection
Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care

Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care

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12:55 min

February 16, 2015

DOI:

12:55 min
February 16, 2015

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Summary

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The lymphodepletive and immunomodulatory effects of chemotherapy and radiation standard of care can be leveraged to enhance the antitumor efficacy of T cell immunotherapy. We outline a method for generating EGFRvIII-specific chimeric antigen receptor (CAR) T cells and administering them in the context of glioblastoma standard of care.

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