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Early Detection of Drug-Induced Renal Hemodynamic Dysfunction Using Sonographic Technology in Rats
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Early Detection of Drug-Induced Renal Hemodynamic Dysfunction Using Sonographic Technology in Rats

Article DOI: 10.3791/52409-v • 06:38 min • March 11th, 2016
March 11th, 2016 •
1, 1, 2, 2
1Cardiac Muscle Research Laboratory, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, 2Renal Division, Brigham and Women's Hospital, Harvard Medical School

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Summary
Automatic Translation

Early stage hemodynamic dysfunction is critical to the development of kidney disease. Yet, detection methodologies are limited. Recent advances in sonography provide a noninvasive, accurate option for early detection of kidney injury. This study outlines a step-by-step, sonographic methodology for detecting kidney dysfunction using a drug-induced nephrotoxicity rat model.

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Early Detection Drug-induced Renal Hemodynamic Dysfunction Sonographic Technology Rats Sonographic Methodology Kidney Dysfunction Drug-induced Nephrotoxicity Rat Model Ultrasound Probe Rail System Aorta B-mode Image Color Doppler Acoustic Window Renal Artery Renal Vein Pulsed Wave PW Yellow Indicator Line Flow Assessment High Resolution Ultrasound Imaging Cisplatin-induced Acute Kidney Injury Renal Function Monitoring Field Hemodynamic Changes Mouse Models
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