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Chapters
- 00:05Title
- 00:51Preparing the Injection Syringe
- 02:55Preparing the Animal
- 03:41Exposing the Spinal Cord
- 05:36Injecting the Spinal Cord
- 07:30Lysolecithin-induced Demyelination
- 08:34Conclusion
Demyelinating diseases can be modeled in animals by focal application of lysolecithin into the CNS. A single injection of lysolecithin into mouse spinal cord produces a lesion that spontaneously repairs over time. The goal is to study factors involved in de- and remyelination, and to test agents for enhancing repair.
