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July 29, 2015
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Summary
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Focal demyelination is induced in the optic nerve using lysolecithin microinjection. Visual evoked potentials are recorded via skull electrodes implanted over the visual cortex to examine the signal conduction along the visual pathway in vivo. This protocol details the surgical procedures underlying electrode implantation and optic nerve microinjection.
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Cite this Article
You, Y., Gupta, V. K., Chitranshi, N., Reedman, B., Klistorner, A., Graham, S. L. Visual Evoked Potential Recording in a Rat Model of Experimental Optic Nerve Demyelination. J. Vis. Exp. (101), e52934, doi:10.3791/52934 (2015).
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