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JoVE Journal
Neuroscience

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Visual Evoked Potential Recording in a Rat Model of Experimental Optic Nerve Demyelination
 

Visual Evoked Potential Recording in a Rat Model of Experimental Optic Nerve Demyelination

Article DOI: 10.3791/52934
July 29th, 2015

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Summary July 29th, 2015

Focal demyelination is induced in the optic nerve using lysolecithin microinjection. Visual evoked potentials are recorded via skull electrodes implanted over the visual cortex to examine the signal conduction along the visual pathway in vivo. This protocol details the surgical procedures underlying electrode implantation and optic nerve microinjection.

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