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Neuroscience

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Selective Depletion of Microglia from Cerebellar Granule Cell Cultures Using L-leucine Methyl Ester
 

Selective Depletion of Microglia from Cerebellar Granule Cell Cultures Using L-leucine Methyl Ester

Article doi: 10.3791/52983
July 7th, 2015

Summary July 7th, 2015

Microglia can influence neurons and other glia in culture by various non-cell autonomous mechanisms. Here, we present a protocol to selectively deplete microglia from primary neuronal cultures. This method has the potential to elucidate the role of microglial-neuronal interactions, with implications for neurodegenerative conditions where neuroinflammation is a hallmark feature.

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