In Vitro Modeling of Cancerous Neural Invasion: The Dorsal Root Ganglion Model

The overall goal of this model is to recapitulate the cancerous neural microenvironment. This enables exploration of cancer cell neuron interactions. This method can help answer key questions in the tumor microenvironment field, such as interaction between tumor cell and neurons and the mutual influence of each set.

The main advantage of this technique is that it is reliable, easy to perform and address both cellular and cerebral factors in the neural niche. The implications of this technique extend towards therapeutic development and pharmacological targeting of key factors in the neural remodeling and invasion process throughout cancer development. After euthanizing the animal in a CO2 chamber, soak the fur with 70%ethanol and allow it to dry.