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Custom-designed Laser-based Heating Apparatus for Triggered Release of Cisplatin from Thermosensitive Liposomes with Magnetic Resonance Image Guidance
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Bioengineering
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JoVE Journal Bioengineering
Custom-designed Laser-based Heating Apparatus for Triggered Release of Cisplatin from Thermosensitive Liposomes with Magnetic Resonance Image Guidance

Custom-designed Laser-based Heating Apparatus for Triggered Release of Cisplatin from Thermosensitive Liposomes with Magnetic Resonance Image Guidance

DOI:
10.3791/53055-v

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07:47 min

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December 13, 2015

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, , , , , ,
1Leslie Dan Faculty of Pharmacy,University of Toronto, 2Department of Radiation Oncology,University of Toronto, 3Medical Biophysics,University of Toronto, 4Institute of Biomaterials & Biomedical Engineering,University of Toronto, 5Techna Institute and Radiation Medicine Program, Princess Margaret Cancer Center,University Health Network, 6STTARR Innovation Center,University Health Network, 7Ontario Cancer Institute,University Health Network

Chapters

  • 00:05Title
  • 02:00Liposome Preparation
  • 03:42Subcutaneous Cervical Tumor Xenograft Implantation
  • 05:08Conformal Tumor Heating via Custom Laser Chamber
  • 06:15Results: Representative Tumor Laser Treatment Analyses
  • 07:12Conclusion

Summary

Automatic Translation

Automatic Translation

AN MRI-compatible custom-designed laser-based heating apparatus has been developed to provide local heating of subcutaneous tumors in order to activate release of agents from thermosensitive liposomes specifically at the tumor region.

Tags

Thermosensitive LiposomesCisplatinLaser-based HeatingMR ThermometryDrug DeliveryTumor TargetingEPR EffectTriggered Drug Release

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