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JoVE Journal
Immunology and Infection

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Anti-virulent Disruption of Pathogenic Biofilms using Engineered Quorum-quenching Lactonases
 

Anti-virulent Disruption of Pathogenic Biofilms using Engineered Quorum-quenching Lactonases

Article DOI: 10.3791/53243
January 1st, 2016

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Summary January 1st, 2016

Quorum-quenching enzymes are anti-virulent and anti-bacterial options that can mitigate pathogenesis without risk of incurring resistance, by preventing the expression of virulence factors and genes associated with antibiotic resistance and biofilm formation. In this study, we report a method that demonstrates the efficacy of quorum-quenching enzymes in bacterial biofilm disruption.

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