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JoVE Journal
Neuroscience
Author Produced
A Simple Alternative to Stereotactic Injection for Brain Specific Knockdown of miRNA
 

A Simple Alternative to Stereotactic Injection for Brain Specific Knockdown of miRNA

Article
December 26th, 2015

Summary December 26th, 2015

MicroRNAs play crucial roles in the brain and are potential targets for modeling neuro-degeneration. However, perturbing miRNA levels is challenging due to the short length of miRNA and inaccessibility of the brain tissue. This video presents a method for antagomir design and brain specific delivery using a neuropeptide in mice.

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