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Immunology and Infection

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JoVE Journal Immunology and Infection
Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice
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Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice

Article DOI: 10.3791/54440-v • 06:32 min • September 19th, 2016
September 19th, 2016 •
1, 1, 1, 1
1Department of Microbiology, University of Zaragoza

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Summary
Automatic Translation

We herein detail the methodology followed to compare protective efficacy and lung immune response induced by intranasal and subcutaneous immunization with BCG in mouse model. Our results show the benefits of pulmonary vaccination and suggest a role for IL17-mediated response in vaccine-induced protection.

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Protective Efficacy Pulmonary Immune Response Subcutaneous BCG Administration Intranasal BCG Administration Tuberculosis Immunization Vaccine-induced Lung Immune Response Lung Immune Protection Specific Immune Parameters Subcutaneous Administration BCG Vaccine Suspension Anesthetized Mouse Rear Flank Intranasal Administration Micro-pipette BCG Suspension Supine Position Inoculum Deposition
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