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1Department of Surgery,University of Maryland School of Medicine, 2Department of Medicine,University of Maryland School of Medicine, 3Department of Radiology,University of Maryland School of Medicine, 4Food and Drug Administration, 5Department of Pharmaceutical Sciences,University of Maryland School of Pharmacy, 6VA Maryland Health Care System
Chapters
- 00:05Title
- 00:5919F-Labeled Bile Acid Gavage, Organ Harvest and Bile Acid Measurement
- 04:02Live Animal Proton (1H) and Fluorine (19F) Magnetic Resonance Imaging (MRI)
- 05:51Results: Representative Multi-fluorinated Bile Acid (MFBA) Measurement in the Mouse Gallbladder
- 07:51Conclusion
Tools om te diagnosticeren galzuurintermediairen malabsorptie en meet galzuur transport in vivo beperkt zijn. Een innovatieve aanpak in levende dieren wordt beschreven dat de gecombineerde proton (1H) plus fluor (19 F) magnetic resonance imaging gebruikt; Deze nieuwe methodologie heeft translationeel potentieel om te screenen op galzuurintermediairen malabsorptie in de klinische praktijk.
