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The Rabbit Model of Accelerated Atherosclerosis

The Rabbit Model of Accelerated Atherosclerosis: A Methodological Perspective of the Iliac Artery Balloon Injury

Article DOI: 10.3791/55295 09:14 min October 3rd, 2017
October 3rd, 2017



Animal models of atherosclerosis are essential to understand the mechanism and to investigate newer approaches to prevent plaque development or rupture, a leading cause of death in the industrialized world. This protocol uses a combination of balloon injury and cholesterol rich diet to induce atherosclerotic plaques in rabbit iliac artery.



Rabbit Model Accelerated Atherosclerosis Iliac Artery Balloon Injury Atherogenic Diet Atherosclerotic Plaques Endothelium Disruption Iliac Artery Similarity To Human Coronary Artery Plaque Composition Study Morphometric And Angiographic Endpoints Surgical Tools Sterilization Balloon Catheter Assemblies Luer Lock Syringe Normal Saline Injection Buprenorphine Injection Rabbit Anesthesia
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