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Genetics

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Single Molecule Analysis of Laser Localized Psoralen Adducts
 

Single Molecule Analysis of Laser Localized Psoralen Adducts

Article doi: 10.3791/55541
April 20th, 2017

Summary April 20th, 2017

Lasers are frequently used in studies of the cellular response to DNA damage. However, they generate lesions whose spacing, frequency, and collisions with replication forks are rarely characterized. Here, we describe an approach that enables the determination of these parameters with laser localized interstrand crosslinks.

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