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A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy
A Mouse 5/6<sup>th</sup> Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy
JoVE Journal
Biology
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JoVE Journal Biology
A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy

20,416 Views

07:52 min

November 07, 2017

DOI:

07:52 min
November 07, 2017

20361 Views
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Summary

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This manuscript provides a detailed two-step surgical procedure to perform mouse 5/6th partial nephrectomy (PNx) with pole ligation. Four weeks after surgery, in comparison with sham-operated mice, the PNx mice developed impaired renal function, anemia, cardiac hypertrophy, cardiac fibrosis, and decreased heart systolic and diastolic function.

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