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A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy
 

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy

Article DOI: 10.3791/55825
November 7th, 2017

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Summary November 7th, 2017

This manuscript provides a detailed two-step surgical procedure to perform mouse 5/6th partial nephrectomy (PNx) with pole ligation. Four weeks after surgery, in comparison with sham-operated mice, the PNx mice developed impaired renal function, anemia, cardiac hypertrophy, cardiac fibrosis, and decreased heart systolic and diastolic function.

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