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JoVE Journal
Neuroscience
Author Produced

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Partial Optic Nerve Transection in Rats
 

Partial Optic Nerve Transection in Rats: A Model Established with a New Operative Approach to Assess Secondary Degeneration of Retinal Ganglion Cells

Article DOI: 10.3791/56272-v 13:12 min October 15th, 2017
October 15th, 2017

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Summary

Secondary degeneration of retinal ganglion cells (RGCs) occurs commonly in glaucoma. This study describes an innovative operative approach for partial optic nerve transection. The use of this space-saving operative approach extends the model's application range, and allows exploration of secondary injury mechanisms in RGCs in a new way.

Tags

Keywords: Partial Optic Nerve Transection Secondary Degeneration Retinal Ganglion Cells Glaucoma Novel Surgical Approach Space-saving Technique Optic Nerve Stabilization Primary And Secondary Injury
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