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Partial Optic Nerve Transection in Rats

Partial Optic Nerve Transection in Rats: A Model Established with a New Operative Approach to Assess Secondary Degeneration of Retinal Ganglion Cells

Article DOI: 10.3791/56272-v 13:12 min October 15th, 2017
October 15th, 2017



Secondary degeneration of retinal ganglion cells (RGCs) occurs commonly in glaucoma. This study describes an innovative operative approach for partial optic nerve transection. The use of this space-saving operative approach extends the model's application range, and allows exploration of secondary injury mechanisms in RGCs in a new way.


Keywords: Partial Optic Nerve Transection Secondary Degeneration Retinal Ganglion Cells Glaucoma Novel Surgical Approach Space-saving Technique Optic Nerve Stabilization Primary And Secondary Injury
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