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JoVE Journal Neuroscience
Un enfoque Simple para inducir Neuritis Autoinmune Experimental en ratones C57BL/6 para las evaluaciones funcionales y Neuropathological
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Un enfoque Simple para inducir Neuritis Autoinmune Experimental en ratones C57BL/6 para las evaluaciones funcionales y Neuropathological

Article DOI: 10.3791/56455-v • 07:30 min • November 9th, 2017
November 9th, 2017 •
1, 1, 1, 1, 1, 1
1Department of Anatomy and Neuroscience, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne

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Este informe describe un enfoque simple para inducir con éxito neuritis autoinmune experimental (EAN) utilizando la mielina proteína cero (P0)180-199 péptido en combinación con adyuvante completo de Freund y toxina del pertussis. Presentamos un paradigma sofisticado capaz de evaluar con precisión la magnitud de los déficits funcionales y neuropatología que ocurren en este EAN.

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Neurociencia número 129 neuritis Autoinmune Experimental daño axonal nodos de Ranvier nervio periférico desmielinización modelo de ratón
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