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The Madagascar Hissing Cockroach as an Alternative Non-mammalian Animal Model to Investigate Virulence, Pathogenesis, and Drug Efficacy
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Immunology and Infection
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JoVE Journal Immunology and Infection
The Madagascar Hissing Cockroach as an Alternative Non-mammalian Animal Model to Investigate Virulence, Pathogenesis, and Drug Efficacy

The Madagascar Hissing Cockroach as an Alternative Non-mammalian Animal Model to Investigate Virulence, Pathogenesis, and Drug Efficacy

DOI:
10.3791/56491-v

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12:21 min

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November 24, 2017

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, , , ,
1Bacteriology Division,United States Army Medical Research Institute of Infectious Diseases, 2Southern Research, 3Headquarters Division,United States Army Medical Research Institute of Infectious Diseases

Chapters

  • 00:05Title
  • 02:08Cockroach Preparation for Experimentation
  • 02:58Bacterial Culture and Drug Preparations
  • 05:06Assembly of the Injector
  • 06:15Cockroach Injections
  • 09:22Results: Pathogenic and Virulence Responses in Hissing Cockroaches
  • 10:57Conclusion

Summary

Automatic Translation

Automatic Translation

We present a protocol to utilize the Madagascar hissing cockroach as an alternative non-mammalian animal model to conduct bacterial virulence, pathogenesis, drug toxicity, drug efficacy, and innate immune response studies.

Tags

Keywords: Madagascar Hissing CockroachAnimal ModelGromphadorhinaMicrobiologyHost-pathogen InteractionsMicrobial PathogenesisVirulence FactorsDrug EfficacyBurkholderiaGalleria WaxwormTemperature AcclimationInjection Procedure

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