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Neuroscience

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Inducing Cre-lox Recombination in Mouse Cerebral Cortex Through In Utero Electroporation
 

Inducing Cre-lox Recombination in Mouse Cerebral Cortex Through In Utero Electroporation

Article DOI: 10.3791/56675
November 17th, 2017

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Summary November 17th, 2017

Cell-autonomous functions of genes in the brain can be studied by inducing loss or gain of function in sparse populations of cells. Here, we describe in utero electroporation to deliver Cre recombinase into sparse populations of developing cortical neurons with floxed genes to cause loss of function in vivo.

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