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The Pilocarpine Model of Temporal Lobe Epilepsy and EEG Monitoring Using Radiotelemetry System in Mice
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The Pilocarpine Model of Temporal Lobe Epilepsy and EEG Monitoring Using Radiotelemetry System in Mice

Article DOI: 10.3791/56831-v • 10:08 min • February 27th, 2018
February 27th, 2018 •
1, 1
1Department of Pharmacology, Catholic Neuroscience Institute, College of Medicine, The Catholic University of Korea

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Summary
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This manuscript describes a method of inducing status epilepticus by systemic pilocarpine injection and of monitoring spontaneous recurrent seizures in live animals using a wireless telemetry video and electroencephalogram system. This protocol can be utilized for studying the pathophysiologic mechanisms of chronic epilepsy, epileptogenesis, and acute seizures.

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Pilocarpine Model Temporal Lobe Epilepsy EEG Monitoring Radiotelemetry System Mice Status Epilepticus Pathophysiology Mechanisms Acute Seizures Epileptogenesis Chronic Epilepsy Mouse Model Spontaneous Recurrent Seizures Survivor Rate Scopolamine Terbutaline Pilocarpine Solution Intraperitoneal Injection Behavior Monitoring Limbic Motor Seizures Racine's Scale
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