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A New Method for Inducing a Depression-Like Behavior in Rats
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JoVE Journal Behavior
A New Method for Inducing a Depression-Like Behavior in Rats

A New Method for Inducing a Depression-Like Behavior in Rats

DOI:
10.3791/57137-v

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07:57 min

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February 22, 2018

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, , , , , , , , ,
1Department of Emergent Medicine, Soroka University Medical Center,Ben-Gurion University of the Negev, 2Division of Anesthesiology and Critical Care, Soroka Medical Center,Ben-Gurion University of the Negev, 3Department of Biophysics and Biochemistry,Oles’ Honchar Dnipro National University

Chapters

  • 00:04Title
  • 00:40Measuring Depression at Baseline
  • 02:31Induction of Depression in Rats
  • 04:03Establishing Depression-contagion in Naïve Rats
  • 04:37Open Field Test
  • 05:08Forced-swim Test
  • 05:50Results: Sucrose Preference, Open Field and Forced Swim Test Performance after Induction of Depression-like Behavior
  • 07:22Conclusion

Summary

Automatic Translation

Automatic Translation

This protocol describes a new model by which healthy rats could contract depression over a given time periodthrough contagion by exposure to chronic unpredictable stressed (CUS) rats.

Tags

Keywords: DepressionContagionRat ModelBehavioral FieldMechanismPreventionContainmentTreatmentTherapySucrose Preference TestChronic Unpredictable StressHousingFood DeprivationWater DeprivationWet BeddingContinuous Lighting

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