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JoVE Journal Cancer Research
A Syngeneic Pancreatic Cancer Mouse Model to Study the Effects of Irreversible Electroporation
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A Syngeneic Pancreatic Cancer Mouse Model to Study the Effects of Irreversible Electroporation

Article DOI: 10.3791/57265-v • 08:05 min • June 8th, 2018
June 8th, 2018 •
1, 1, 2, 1
1Moores Cancer Center, University California San Diego, 2Duke University School of Medicine

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Summary
Automatic Translation

Irreversible electroporation (IRE) is a non-thermal ablation technique used for the treatment of locally advanced pancreatic cancer. Being a relatively new technique, the effects of IRE on the tumor growth are poorly understood. We have developed a syngeneic mouse model that facilitates studying the effects of IRE on pancreatic cancer.

Tags

Syngeneic Pancreatic Cancer Mouse Model Irreversible Electroporation (IRE) Local Tumor Microenvironment Accurate Tumor Growth Assessment Immunocompetent System Subcutaneous Tumor Induction C57 Black Six Mouse Basement Membrane Matrix Tumor Cell Suspension Injection Site Cleaning
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