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JoVE Journal
Biology

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De Novo Generation of Somatic Stem Cells by YAP/TAZ
 

De Novo Generation of Somatic Stem Cells by YAP/TAZ

Article DOI: 10.3791/57462
May 7th, 2018

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Summary May 7th, 2018

Availability of somatic SCs is crucial for regenerative medicine, disease modeling and to gain insight into SC properties. Here we present experimental strategies to reprogram, in vitro, differentiated adult cells into their corresponding expandable tissue-specific stem/progenitor cells by the transient expression of the single transcriptional co-activator YAP.

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