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JoVE Journal
Cancer Research

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Virus Delivery of CRISPR Guides to the Murine Prostate for Gene Alteration
 

Virus Delivery of CRISPR Guides to the Murine Prostate for Gene Alteration

Article DOI: 10.3791/57525
April 27th, 2018

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Summary April 27th, 2018

This protocol describes a newly established method for virus delivery to the murine prostate. Using either CRISPR/Cas9 technology, gene overexpression, or Cre recombinase delivery, the technique allows orthotopic alteration of gene expression and implements a novel mouse model for prostate cancer.

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