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JoVE Journal Neuroscience
Cochlear Implant Surgery and Electrically-evoked Auditory Brainstem Response Recordings in C57BL/6 Mice
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Cochlear Implant Surgery and Electrically-evoked Auditory Brainstem Response Recordings in C57BL/6 Mice

Article DOI: 10.3791/58073-v • 09:06 min • January 9th, 2019
January 9th, 2019 •
1,2, 1, 2
1Hearing Systems Group, Department of Electrical Engineering, Technical University of Denmark, 2Brain and Sound Lab, Department of Biomedicine, Basel University

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Summary
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Animal models of cochlear implants can advance knowledge of the technological bases of treating permanent sensorineural hearing loss with electrical stimulation. This study presents a surgical protocol for acute deafening and cochlear implantation of an electrode array in mice as well as the functional assessment with auditory brainstem response.

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Cochlear Implant Surgery Electrically-evoked Auditory Brainstem Response Recordings C57BL/6 Mice Animal Models Sensory Neural Hearing Loss Electric Stimulation Acute Deafening Cochlear Implantation Functional Assessment Auditory Brain Stem Response Challenges Small Size Of The Cochlea Stapedial Artery Normal Hearing Status Acoustic Foam Injection Contralateral Ear Canal Ipsilateral Ear AVR Electrodes Reference Electrode Active Electrode Ground Electrode Headstage And Preamplifier Auditory Processor Impedance
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