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Developmental Biology

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JoVE Journal Developmental Biology
Brug af hæmatopoietisk stamcelletransplantation at vurdere oprindelsen af myelodysplastisk syndrom
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Brug af hæmatopoietisk stamcelletransplantation at vurdere oprindelsen af myelodysplastisk syndrom

Article DOI: 10.3791/58140-v • 06:39 min • October 3rd, 2018
October 3rd, 2018 •
1, 1, 2, 1
1Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 2LGI Flow Cytometry Core Facility, Center for Cancer Research, National Cancer Institute, National Institutes of Health

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Vi beskriver brugen af hæmatopoietisk stamcelletransplantation (HSCT) til at vurdere det maligne potentiale af gensplejsede hæmatopoietisk celler. HSCT er nyttigt for evaluering af forskellige maligne hæmatopoietisk celler i vivo samt generere en stor kohorte af mus med myelodysplastisk syndrom (MDS) eller leukæmi for at evaluere nye behandlingsformer.

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Udviklingsmæssige biologi spørgsmål 140 myelodysplastisk syndromer hæmatopoietisk stamcelletransplantation fluorescens-aktiveret celle sortering knoglemarv NUP98-HOXD13 akut myeloid leukæmi hæmatopoietisk malignitet
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