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JoVE Journal
Cancer Research

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Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence
 

Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence

Article DOI: 10.3791/58194
January 7th, 2019

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Summary January 7th, 2019

Here, we describe protocols for the genetic and chemical validation of c-Fos and Dusp1 as a drug target in leukemia using in vitro and in vivo genetic and humanized mouse models. This method can be applied to any target for genetic validation and therapeutic development.

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