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September 26, 2018
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We describe a protocol to induce atherosclerosis in the aortic root of ApoE-/- mice fed with an atherogenic diet, through a continuous release of aldosterone. Methods to characterize plaque composition are also described.
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Cite this Article
Marzolla, V., Armani, A., Mammi, C., Feraco, A., Caprio, M. Induction of Atherosclerotic Plaques Through Activation of Mineralocorticoid Receptors in Apolipoprotein E-deficient Mice. J. Vis. Exp. (139), e58303, doi:10.3791/58303 (2018).
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