This article describes a straightforward method to prepare small animal brains for micro-CT imaging, in which lesions can be quantified and electrodes located with high precision in the context of the whole brain.
Masis, J., Mankus, D., Wolff, S. B., Guitchounts, G., Joesch, M., Cox, D. D. A Micro-CT-based Method for Characterizing Lesions and Locating Electrodes in Small Animal Brains. J. Vis. Exp. (141), e58585, doi:10.3791/58585 (2018).