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Behavioral Assessments of Spontaneous Locomotion in a Murine MPTP-induced Parkinson’s Disease Model
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Behavior
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JoVE Journal Behavior
Behavioral Assessments of Spontaneous Locomotion in a Murine MPTP-induced Parkinson’s Disease Model

Behavioral Assessments of Spontaneous Locomotion in a Murine MPTP-induced Parkinson’s Disease Model

DOI:
10.3791/58653-v

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05:38 min

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January 07, 2019

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, , , , , ,
1State Key Laboratory of Medicinal Chemical Biology, The Key Laboratory of Bioactive Materials, Ministry of Education, College of Life Science,Nankai University

Chapters

  • 00:04Title
  • 00:42Cylinder Test
  • 02:44Open Field Test
  • 03:36Results: Performance on the Cylinder and Open Field Tests Following MPTP Administration
  • 04:49Conclusion

Summary

Automatic Translation

Automatic Translation

We describe establishment of a murine model for Parkinson's disease using MPTP, and behavioral assessments using cylinder and open field tests to measure motor function. We then use L-DOPA as one example to show how to apply this model in the study of PD drugs.

Tags

Keywords: Behavioral AssessmentSpontaneous LocomotionMPTP-inducedParkinson’s Disease ModelCylinder TestOpen Field TestPaw LiftMotor FunctionL-DOPAVideo RecordingEnvironmental InterferenceAcclimationSanitization

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