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JoVE Journal Medicine
Non-invasive Assessment of Dorsiflexor Muscle Function in Mice
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Non-invasive Assessment of Dorsiflexor Muscle Function in Mice

Article DOI: 10.3791/58696-v • 05:31 min • January 17th, 2019
January 17th, 2019 •
1, 2, 3, 4, 5, 4, 4
1School of Exercise and Nutrition Sciences, Deakin University, 2Centre for Molecular and Medical Research, School of Medicine, Deakin University, 3Department of Orthopaedics, School of Medicine, University of Maryland, 4Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, 5Department of Physiology, Anatomy and Microbiology, La Trobe University

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Summary
Automatic Translation

Measurement of rodent skeletal muscle contractile function is a useful tool that can be used to track disease progression as well as efficacy of therapeutic intervention. We describe here the non-invasive, in vivo assessment of the dorsiflexor muscles that can be repeated over time in the same mouse.

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Non-invasive Assessment Dorsiflexor Muscle Function Mice Muscle Contraction Function Force Production Mechanism Disease Progression Non-invasive Procedure Same Animal Different Time Points Monitor Disease Progression Treatment Visual Demonstration Consistent Results Mouse Knee Clamp Mouse Footplate Heating Platform Dynamic Muscle Control Software Run Time Parameters Autosave Base Enable Autosave DMC Control Screen Sequencer Open Sequence Load Sequence Prepare The Animal For Experiment Remove Hair
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