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Neuroscience

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JoVE Journal Neuroscience
Effects of Blast-induced Neurotrauma on Pressurized Rodent Middle Cerebral Arteries
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Effects of Blast-induced Neurotrauma on Pressurized Rodent Middle Cerebral Arteries

Article DOI: 10.3791/58792-v • 08:21 min • April 1st, 2019
April 1st, 2019 •
1,2, 1,2, 1,2, 1,2, 1,2, 1,2
1Charles R. Allen Research Laboratories, Department of Anesthesiology, University of Texas Medical Branch, 2The Moody Project for Translational Traumatic Brain Injury Research, University of Texas Medical Branch

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Summary
Automatic Translation

Here, we present a protocol to describe methods for ex vivo vascular reactivity determination following a primary blast traumatic brain injury (bTBI) using isolated, pressurized, rodent middle cerebral arterial (MCA) segments. bTBI induction is accomplished using a shock tube, also known as an Advanced Blast Simulator (ABS) device.

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Blast-induced Neurotrauma Pressurized Rodent Middle Cerebral Arteries Cerebral Vascular Injury Myogenic Vascular Response Isolated Pressurized Arterial Preparation Blast Exposure Vascular Function Stroke Hypertension Diabetes Therapies Cerebral Circulation Hemorrhage Blast Simulator ABS Mylar Sheets Mylar Membrane Expansion Chamber Driver Chamber Hydraulic Hand Pump
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