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JoVE Journal
Immunology and Infection

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A Mouse Model to Assess Innate Immune Response to Staphylococcus aureus Infection
 

A Mouse Model to Assess Innate Immune Response to Staphylococcus aureus Infection

Article doi: 10.3791/59015
February 28th, 2019

Summary February 28th, 2019

An approach is described for real-time detection of the innate immune response to cutaneous wounding and Staphylococcus aureus infection of mice. By comparing LysM-EGFP mice (which possess fluorescent neutrophils) with a LysM-EGFP crossbred immunodeficient mouse strain, we advance our understanding of infection and the development of approaches to combat infection.

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