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Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction
 

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction

Article doi: 10.3791/59041
January 29th, 2019 Usage Statistics

Summary January 29th, 2019

This protocol describes the synthesis and characterization of a trans-cyclooctene (TCO)-modified antibody and a 177Lu-labeled tetrazine (Tz) radioligand for pretargeted radioimmunotherapy (PRIT). In addition, it details the use of these two constructs for in vivo biodistribution and longitudinal therapy studies in a murine model of colorectal cancer.

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