Brian M. Zeglis

Department of Radiology, Memorial Sloan Kettering Cancer Center

Affiliated withMemorial Sloan Kettering Cancer Center Graduate Center of City University of New York Hunter College of The City University of New York

Research Area

Biography

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JoVE Journal Publications

ArticleTotal : 5	Year
Publication title Cited by 7	2015
Publication title Cited by 81	2015
Publication title	2017
Publication title Cited by 11	2019
Publication title Cited by 8	2019

Other Publications

Article	Year
Unexpected oxidative C-C cleavage in the metallation of 2-substituted imidazolium salts to give N-heterocyclic carbene complexes. Chemical communications (Cambridge, England)\| PubMed ID: 15467859	2004
A mismatch-selective bifunctional rhodium-Oregon Green conjugate: a fluorescent probe for mismatched DNA. Journal of the American Chemical Society\| PubMed ID: 16637630	2006
DNA base mismatch detection with bulky rhodium intercalators: synthesis and applications. Nature protocols\| PubMed ID: 17406597	2007
Metallo-intercalators and metallo-insertors. Chemical communications (Cambridge, England)\| PubMed ID: 17989802	2007
Targeting abasic sites and single base bulges in DNA with metalloinsertors. Journal of the American Chemical Society\| PubMed ID: 18491905	2008
Binding of Ru(bpy)2(eilatin)2+ to matched and mismatched DNA. Inorganic chemistry\| PubMed ID: 18576614	2008
Recognition of abasic sites and single base bulges in DNA by a metalloinsertor. Biochemistry\| PubMed ID: 19146409	2009
A bulky rhodium complex bound to an adenosine-adenosine DNA mismatch: general architecture of the metalloinsertion binding mode. Biochemistry\| PubMed ID: 19374348	2009
Role of metalation in the topoisomerase IIα inhibition and antiproliferation activity of a series of α-heterocyclic-N4-substituted thiosemicarbazones and their Cu(II) complexes. Journal of medicinal chemistry\| PubMed ID: 21391686	2011
A practical guide to the construction of radiometallated bioconjugates for positron emission tomography. Dalton transactions (Cambridge, England : 2003)\| PubMed ID: 21442098	2011
The synthesis and evaluation of N1-(4-(2-[18F]-fluoroethyl)phenyl)-N8-hydroxyoctanediamide ([18F]-FESAHA), a PET radiotracer designed for the delineation of histone deacetylase expression in... Nuclear medicine and biology\| PubMed ID: 21718944	2011
Modular strategy for the construction of radiometalated antibodies for positron emission tomography based on inverse electron demand Diels-Alder click chemistry. Bioconjugate chemistry\| PubMed ID: 21877749	2011
PET imaging with ⁸⁹Zr: from radiochemistry to the clinic. Nuclear medicine and biology\| PubMed ID: 22998840	2013
H(2)azapa: a versatile acyclic multifunctional chelator for (67)Ga, (64)Cu, (111)In, and (177)Lu. Inorganic chemistry\| PubMed ID: 23106422	2012
The growing impact of bioorthogonal click chemistry on the development of radiopharmaceuticals. Journal of nuclear medicine : official publication, Society of Nuclear Medicine\| PubMed ID: 23616581	2013
Enzyme-mediated methodology for the site-specific radiolabeling of antibodies based on catalyst-free click chemistry. Bioconjugate chemistry\| PubMed ID: 23688208	2013
A Pretargeted PET Imaging Strategy Based on Bioorthogonal Diels-Alder Click Chemistry. Journal of nuclear medicine : official publication, Society of Nuclear Medicine\| PubMed ID: 23708196	2013
H(4)octapa-trastuzumab: versatile acyclic chelate system for 111In and 177Lu imaging and therapy. Journal of the American Chemical Society\| PubMed ID: 23901833	2013
H6phospa-trastuzumab: bifunctional methylenephosphonate-based chelator with 89Zr, 111In and 177Lu. Dalton transactions (Cambridge, England : 2003)\| PubMed ID: 24104523	2014
Underscoring the influence of inorganic chemistry on nuclear imaging with radiometals. Inorganic chemistry\| PubMed ID: 24313747	2014
The inverse electron demand Diels-Alder click reaction in radiochemistry. Journal of labelled compounds & radiopharmaceuticals\| PubMed ID: 24347429	2014
Building Blocks for the Construction of Bioorthogonally Reactive Peptides via Solid-Phase Peptide Synthesis. ChemistryOpen\| PubMed ID: 24808990	2014
Alternative chelator for ⁸⁹Zr radiopharmaceuticals: radiolabeling and evaluation of 3,4,3-(LI-1,2-HOPO). Journal of medicinal chemistry\| PubMed ID: 24814511	2014
Synthesis of the first radiolabeled 188Re N-heterocyclic carbene complex and initial studies on its potential use in radiopharmaceutical applications. Journal of labelled compounds & radiopharmaceuticals\| PubMed ID: 24889257	2014
What a difference a carbon makes: H₄octapa vs H₄C3octapa, ligands for In-111 and Lu-177 radiochemistry. Inorganic chemistry\| PubMed ID: 25192223	2014
Synthesis and evaluation of (18)F-labeled ATP competitive inhibitors of topoisomerase II as probes for imaging topoisomerase II expression. European journal of medicinal chemistry\| PubMed ID: 25240701	2014
Chemoenzymatic strategy for the synthesis of site-specifically labeled immunoconjugates for multimodal PET and optical imaging. Bioconjugate chemistry\| PubMed ID: 25418333	2014
Optimization of a Pretargeted Strategy for the PET Imaging of Colorectal Carcinoma via the Modulation of Radioligand Pharmacokinetics. Molecular pharmaceutics\| PubMed ID: 26287993	2015
Pretargeted Immuno-PET of Pancreatic Cancer: Overcoming Circulating Antigen and Internalized Antibody to Reduce Radiation Doses. Journal of nuclear medicine : official publication, Society of Nuclear Medicine\| PubMed ID: 26471693	2016
(18)F-Based Pretargeted PET Imaging Based on Bioorthogonal Diels-Alder Click Chemistry. Bioconjugate chemistry\| PubMed ID: 26479967	2016
Site-specifically labeled CA19.9-targeted immunoconjugates for the PET, NIRF, and multimodal PET/NIRF imaging of pancreatic cancer. Proceedings of the National Academy of Sciences of the United States of America\| PubMed ID: 26668398	2015
Site-Specifically Labeled Immunoconjugates for Molecular Imaging--Part 1: Cysteine Residues and Glycans. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging\| PubMed ID: 26754790	2016
Site-Specifically Labeled Immunoconjugates for Molecular Imaging--Part 2: Peptide Tags and Unnatural Amino Acids. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging\| PubMed ID: 26754791	2016
Preclinical 89Zr Immuno-PET of High-Grade Serous Ovarian Cancer and Lymph Node Metastasis. Journal of nuclear medicine : official publication, Society of Nuclear Medicine\| PubMed ID: 26837339	2016
Molecular Imaging of Ovarian Cancer. Journal of nuclear medicine : official publication, Society of Nuclear Medicine\| PubMed ID: 27127223	2016
Pretargeted PET Imaging Using a Site-Specifically Labeled Immunoconjugate. Bioconjugate chemistry\| PubMed ID: 27356886	2016
A comparative evaluation of the chelators H4octapa and CHX-A″-DTPA with the therapeutic radiometal (90)Y. Nuclear medicine and biology\| PubMed ID: 27419360	2016
Near-Infrared Intraoperative Chemiluminescence Imaging. ChemMedChem\| PubMed ID: 27471800	2016
A Bone-Seeking trans-Cyclooctene for Pretargeting and Bioorthogonal Chemistry: A Proof of Concept Study Using (99m)Tc- and (177)Lu-Labeled Tetrazines. Journal of medicinal chemistry\| PubMed ID: 27676258	2016
Click Chemistry and Radiochemistry: The First 10 Years. Bioconjugate chemistry\| PubMed ID: 27787983	2016
A Pretargeted Approach for the Multimodal PET/NIRF Imaging of Colorectal Cancer. Theranostics\| PubMed ID: 27924162	2016
Establishment of the In Vivo Efficacy of Pretargeted Radioimmunotherapy Utilizing Inverse Electron Demand Diels-Alder Click Chemistry. Molecular cancer therapeutics\| PubMed ID: 28062708	2017
ESPMIS: Helping Young Scientists Navigate the Molecular Imaging Landscape. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging\| PubMed ID: 28194633	2017
Pretargeted Imaging and Therapy. Journal of nuclear medicine : official publication, Society of Nuclear Medicine\| PubMed ID: 28687600	2017
Exploring Structural Parameters for Pretargeting Radioligand Optimization. Journal of medicinal chemistry\| PubMed ID: 28857566	2017
Site-Specifically Labeled Antibody-Drug Conjugate for Simultaneous Therapy and ImmunoPET. Molecular pharmaceutics\| PubMed ID: 29356543	2018
Click-Mediated Pretargeted Radioimmunotherapy of Colorectal Carcinoma. Molecular pharmaceutics\| PubMed ID: 29502416	2018
Thiol-Reactive Bifunctional Chelators for the Creation of Site-Selectively Modified Radioimmunoconjugates with Improved Stability. Bioconjugate chemistry\| PubMed ID: 29509393	2018
Understanding the in vivo fate of radioimmunoconjugates for nuclear imaging. Journal of labelled compounds & radiopharmaceuticals\| PubMed ID: 29665104	2018
Dendrimer Scaffold for the Amplification of In Vivo Pretargeting Ligations. Bioconjugate chemistry\| PubMed ID: 29969558	2018
Leveraging Bioorthogonal Click Chemistry to Improve Ac-Radioimmunotherapy of Pancreatic Ductal Adenocarcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 30352909	2019