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Journal / Immunology and Infection / 诱导BALB/c小鼠药物诱导的自身免疫性肝炎研究其致病机制…
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Immunology and Infection

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JoVE Journal Immunology and Infection
诱导BALB/c小鼠药物诱导的自身免疫性肝炎研究其致病机制
Intravital Microscopy of the Spleen: Quantitative Analysis of Parasite Mobility and Blood Flow
Journal (Immunology and Infection)
Intravital Microscopy of the Spleen: Quantitative Analysis of Parasite Mobility and Blood Flow
Evaluation of the Efficacy And Toxicity of RNAs Targeting HIV-1 Production for Use in Gene or Drug Therapy
Journal (Immunology and Infection)
Evaluation of the Efficacy And Toxicity of RNAs Targeting HIV-1 Production for Use in Gene or Drug Therapy
 
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诱导BALB/c小鼠药物诱导的自身免疫性肝炎研究其致病机制

Article DOI: 10.3791/59174-v • 11:36 min • May 29th, 2020
May 29th, 2020 •
1, 1, 1, 1, 1,2
1Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, 2Department of Pediatrics and Pathology, Johns Hopkins University

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我们描述了BALB / c小鼠中的体内免疫，转化性肝炎模型，可用于研究药物诱导的自身免疫性肝炎的发病机制，包括该疾病中看到的性别差异。我们将描述该模型如何使用体内和体外实验技术演示可重复的分析。

Tags

免疫学和感染， 问题 159， 肝炎， 药物诱导， 免疫介导， 自身免疫， 细胞色素P450 2E， 自身抗体， 线粒体， 氧化应激， Foxp3+Tregs， 性别
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