Electrophoretic Delivery of &#x3B3;-aminobutyric Acid (GABA) into Epileptic Focus Prevents Seizures in Mice

Andrea Slezia; Christopher  M. Proctor; Attila Kaszas; George  G. Malliaras; Adam Williamson

doi:10.3791/59268

Journal

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Neuroscience

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Electrophoretic Delivery of γ-aminobutyric Acid (GABA) into Epileptic Focus Prevents Seizures in Mice

JoVE Journal
Neuroscience

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JoVE Journal Neuroscience

Electrophoretic Delivery of γ-aminobutyric Acid (GABA) into Epileptic Focus Prevents Seizures in Mice

9,016 Views

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07:01 min

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May 16, 2019

DOI:

10.3791/59268-v

DOI:

10.3791/59268-v

•

07:01 min

May 16, 2019

•

8994 Views

Andrea Slezia*^1,5, Christopher M. Proctor*^2,3, Attila Kaszas^1,4, George G. Malliaras^2,3, Adam Williamson^1,5

¹Aix Marseille Université, Institut de Neurosciences des Systèmes (INS)²Electrical Engineering Division,University of Cambridge ³Department of Bioelectronics,Centre Microélectronique de Provence – Ecole Nationale Supérieure des Mines de Saint-Étienne (CMP-EMSE)⁴Institut de Neurosciences de la Timone,Centre National de la Recherche Scientifique (CNRS) UMR 7289 & Aix- Marseille Université ⁵Neuroengineering Research Group, Interdisciplinary Excellence Center, Department of Medical Microbiology and Immunobiology,University of Szeged

Summary

The challenge of epilepsy research is to develop novel treatments for patients where classical therapy is inadequate. Using a new protocol—with the help of an implantable drug delivery system—we are able to control seizures in anesthetized mice by the electrophoretic delivery of GABA into the epileptic focus.