/
/
Electrophoretic Delivery of γ-aminobutyric Acid (GABA) into Epileptic Focus Prevents Seizures in Mice
A subscription to JoVE is required to view this content. Sign in or start your free trial.
1Aix Marseille Université, Institut de Neurosciences des Systèmes (INS), 2Electrical Engineering Division,University of Cambridge, 3Department of Bioelectronics,Centre Microélectronique de Provence – Ecole Nationale Supérieure des Mines de Saint-Étienne (CMP-EMSE), 4Institut de Neurosciences de la Timone,Centre National de la Recherche Scientifique (CNRS) UMR 7289 & Aix- Marseille Université, 5Neuroengineering Research Group, Interdisciplinary Excellence Center, Department of Medical Microbiology and Immunobiology,University of Szeged
Chapters
- 00:04Title
- 00:56Craniotomy
- 02:23Multichannel Silicon Probe and Microfluidic Ion Pump (μFIP) Insertion
- 04:23Seizure Induction
- 05:26Results: Representative Multichannel Recording and Seizure Response Analysis
- 06:26Conclusion
The challenge of epilepsy research is to develop novel treatments for patients where classical therapy is inadequate. Using a new protocol—with the help of an implantable drug delivery system—we are able to control seizures in anesthetized mice by the electrophoretic delivery of GABA into the epileptic focus.
