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JoVE Journal Cancer Research
An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
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An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis

Article DOI: 10.3791/59368-v • 06:38 min • September 12th, 2019
September 12th, 2019 •
*1,2,3, *1,2, 1,2, 1,2, 1,2, 1,2, 1,2,3
1Department of Surgery, University of Missouri-Columbia, 2Ellis Fischel Cancer Center, University of Missouri-Columbia, 3Molecular Microbiology and Immunology, University of Missouri-Columbia
* These authors contributed equally

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Summary
Automatic Translation

Here, we describe the development of a clinically relevant murine model of liver cancer recapitulating the typical immune features of hepatocellular cancer (HCC).

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Oncogenic Hepatocyte-induced Orthotopic Mouse Model Hepatocellular Cancer Hepatic Inflammation Fibrosis Tumor Immunotolerance Specific Treatment-induced Immunoresponses Liver Fibrosis Technique Human Liver Cancer Hepatocellular Cancer Immunological Study Intrasplenic Injection Male C57 Black 6 Mouse Carbon Tetrachloride Supine Position Midline Laparotomy Incision Linea Alba Inferior Vena Cava
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