Waiting
Login processing...

Trial ends in Request Full Access Tell Your Colleague About Jove
JoVE Journal
Neuroscience

A subscription to JoVE is required to view this content.
You will only be able to see the first 2 minutes.

Non-invasive Strategies for Chronic Manipulation of DREADD-controlled Neuronal Activity
 

Non-invasive Strategies for Chronic Manipulation of DREADD-controlled Neuronal Activity

Article DOI: 10.3791/59439-v 08:28 min
August 25th, 2019

Chapters

Summary August 25th, 2019

Here we describe two non-invasive methods to chronically control neuronal activity using chemogenetics in mice. Eye-drops were used to deliver clozapine-N-oxide (CNO) daily. We also describe two methods for prolonged administration of CNO in drinking water. These strategies for chronic neuronal control require minimal intervention reducing animals’ stress.

Transcript

Read Article

Get cutting-edge science videos from JoVE sent straight to your inbox every month.

Waiting X
Simple Hit Counter