An Advanced Murine Model for Nonalcoholic Steatohepatitis in Association with Type 2 Diabetes

Julia Sbierski-Kind; Katharina Schmidt-Bleek; Mathias Streitz; Jonas Kath; Joachim Spranger; Hans-Dieter Volk

doi:10.3791/59470

Journal

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Immunology and Infection

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Tip 2 diyabet ile Ilişkisi olmayan alkollü steatohepatit için gelişmiş bir Murine modeli

An Advanced Murine Model for Nonalcoholic Steatohepatitis in Association with Type 2 Diabetes

JoVE Journal
Immunology and Infection

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JoVE Journal Immunology and Infection

An Advanced Murine Model for Nonalcoholic Steatohepatitis in Association with Type 2 Diabetes

Tip 2 diyabet ile Ilişkisi olmayan alkollü steatohepatit için gelişmiş bir Murine modeli

Please note that all translations are automatically generated. Click here for the English version.

6,989 Views

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10:17 min

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April 26, 2019

DOI:

10.3791/59470-v

DOI:

10.3791/59470-v

•

10:17 min

April 26, 2019

•

6977 Views

Julia Sbierski-Kind^1,2,3,4, Katharina Schmidt-Bleek^3,6, Mathias Streitz^3,5, Jonas Kath^3,5, Joachim Spranger*^1,2,4, Hans-Dieter Volk*^2,3,5

¹Department of Endocrinology & Metabolism Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin,Humboldt-Universität zu Berlin ²Berlin Institute of Health (BIH)³Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin,Humboldt-Universität zu Berlin ⁴DZHK (German Centre for Cardiovascular Research)⁵Institute of Medical Immunology, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin,Humboldt-Universität zu Berlin ⁶Julius Wolff Institute (JWI) and Center for Musculoskeletal Surgery, Charité – Universitätsmedizin Berlin, Berlin, Germany, corporate member of Freie Universität Berlin,Humboldt-Universität zu Berlin

Summary

Alkolsüz steatohepatiti için basit ve güvenilir bir diyet kaynaklı kemirgen hayvan modeli (NASH) tarif edilir, hayvanlar ve özel bir yüksek yağ diyet uygulanması SPF olmayan konut aracılığıyla elde. Biz karaciğer ve adipoz immün hücre alt kümeleri tanımlamak için insan immünolojik koşulları farları çevresel mikroplar maruz tarafından yeniden tanımlamakta.