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JoVE Journal Chemistry
Technical Aspect of the Automated Synthesis and Real-Time Kinetic Evaluation of [11C]SNAP-7941
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Technical Aspect of the Automated Synthesis and Real-Time Kinetic Evaluation of [11C]SNAP-7941

Article DOI: 10.3791/59557-v • 09:50 min • April 28th, 2019
April 28th, 2019 •
1, 1, 1, 1,2, 1, 1,3, 1,4, 1
1Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, 2Department for Pharmaceutical Technology and Biopharmaceutics, Faculty of Life Sciences, University of Vienna, 3Ludwig Boltzmann Institute Applied Diagnostics, 4CBmed GmbH - Center for Biomarker Research in Medicine

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Summary
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Here, we represent a protocol for the fully automated radiolabelling of [11C]SNAP-7941 and the analysis of the real-time kinetics of this PET-tracer on P-gp expressing and non-expressing cells.

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Automated Synthesis Real-time Kinetic Evaluation Carbon-11 Radiolabeling Positron Emission Tomography PET Molecule Receptor Expression Levels Carbon-11 SNAP Synthesis Melanin-concentrating Hormone Receptor Obesity Diabetes Efflux Transporters Blood-brain Barrier Radiopharmaceuticals Central Receptor Expression Imaging In Vitro Evaluation Low Molecular Weight Compounds Methyl Group Senior PhD Students Sarah Pfaff And Theresa Balber
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