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JoVE Journal
Cancer Research

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Fully Human Tumor-based Matrix in Three-dimensional Spheroid Invasion Assay
 

Fully Human Tumor-based Matrix in Three-dimensional Spheroid Invasion Assay

Article doi: 10.3791/59567
May 7th, 2019

Summary May 7th, 2019

Tumor microenvironment is an essential part of cancer growth and invasion. To mimic carcinoma progression, a biologically relevant human matrix is needed. This protocol introduces an improvement for the in vitro three-dimensional spheroid invasion assay by applying a human leiomyoma-based matrix. The protocol also introduces a computer-based cell invasion analysis.

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