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A Novel and Translational Rat Model of Concussion Combining Force and Rotation with In Vivo Cerebral Microdialysis
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Chapters
- 00:04Title
- 01:09Microdialysis Guide Cannula Implantation
- 03:54Microdialysis Procedure
- 05:18Concussion Apparatus Installation
- 06:20Concussion and Sham Induction
- 07:38Results: Righting Reflex Time and Extracellular Concentrations of Glutamate
- 08:12Conclusion
Neurotransmitter alteration is a mechanism of neural dysfunction that occurs after concussion and contributes to the sometimes-catastrophic long-term consequences. This rat model combines microdialysis, allowing in vivo neurotransmitter quantification, with a weight-drop technique exerting rapid acceleration and deceleration of the head and torso, an important factor of human craniocerebral trauma.
