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JoVE Journal
Immunology and Infection

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Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
 

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Article doi: 10.3791/59667
January 21st, 2020 Usage Statistics

Summary January 21st, 2020

This article presents a protocol for establishing a ligature-induced model of murine periodontitis involving multiple maxillary molars, resulting in larger areas of the involved gingival tissue and bone for subsequent analysis as well as reduced animal usage. A technique to assess oral neutrophils in a manner analogous to human subjects is also described.

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