A subscription to JoVE is required to view this content. Sign in or start your free trial.
1Department of General Surgery, The First Affiliated Hospital,Xi’an Jiaotong University, 2Institute of Medical Research,Northwestern Polytechnical University, 3School of Life Sciences,Northwestern Polytechnical University, 4Department of Medicine,Xi’an Jiaotong University, 5Princess Margaret Cancer Center,University of Health Network, 6Department of Pathology,Nanjing Medical University
Chapters
- 00:00Title
- 01:11Mice Appendectomy
- 05:11Induction of Colitis-associated Colorectal Cancer with Azoxymethane (AOM) and Dextran Sodium Sulfate (DSS)
- 06:36Results
- 07:57Conclusion
The presented protocol describes a facile surgical removal of the appendix (caecal patch) in a mouse followed by the induction of inflammatory bowel disease-associated colorectal cancer. This murine appendectomy model enables investigation of the biological role of the appendix in the pathogenesis of human gastrointestinal disease.
