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JoVE Journal
Cancer Research

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A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions
 

A Data Integration Workflow to Identify Drug Combinations Targeting Synthetic Lethal Interactions

Article DOI: 10.3791/60328-v
May 27th, 2021

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Summary May 27th, 2021

Large genetic screens in model organisms have led to the identification of negative genetic interactions. Here, we describe a data integration workflow using data from genetic screens in model organisms to delineate drug combinations targeting synthetic lethal interactions in cancer.

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