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Journal / Medicine / Vinyl klorid og højt fedtindhold kost som en…
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Vinyl klorid og højt fedtindhold kost som en model for miljø og fedme interaktion
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Vinyl klorid og højt fedtindhold kost som en model for miljø og fedme interaktion

Article DOI: 10.3791/60351-v • 09:15 min • January 12th, 2020
January 12th, 2020 •
1,2, 3,4, 5,6, 6,7, 6,7
1Department of Pharmacology and Toxicology, University of Louisville, 2Hepatobiology and Toxicology Program, University of Louisville, 3Department of Physiology and Pharmacology, West Virginia University, 4Center for Inhalation Toxicology, West Virginia University, 5Department of Pharmacology and Chemical Biology, University of Pittsburgh, 6Pittsburgh Liver Research Center, University of Pittsburgh, 7Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh

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Målet med denne protokol var at udvikle en murine model af lav-niveau toksin eksponering, der ikke forårsager åbenlys leverskade, men snarere forværrer præ-eksisterende leverskader. Dette paradigme bedre rekapitulerer menneskelig eksponering og de subtile ændringer, der opstår ved udsættelse for toksin koncentrationer, der betragtes som sikre.

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Medicin vinylchlorid chloroethen indånding miljø toksiske stoffer kemikalier organoklor leversygdom flygtige organiske forbindelser toksisk-associeret steatohepatitis ikke-alkoholiske fedt leversygdom
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