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Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
JoVE Journal
Chemistry
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JoVE Journal Chemistry
Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

DOI:
10.3791/60442-v

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09:34 min

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February 06, 2020

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, ,
1Department of Chemical Engineering,University of Michigan, 2Department of Chemical Engineering,Monash University, 3Department of Materials Science and Engineering,Monash University

Chapters

  • 00:05Introduction
  • 01:20Solid-phase Submonomer Synthesis of Oligo(peptoids)
  • 06:01Sequence-selective Ladder Self-assembly Through Dissociation/Extraction/Annealing
  • 07:22Results: Analysis of Information-bearing Peptoids and Their Sequence-directed Dynamic Covalent Self-assembly
  • 08:31Conclusion

Summary

Automatic Translation

Automatic Translation

A protocol is presented for the synthesis of information-encoded peptoid oligomers and for the sequence-directed self-assembly of these peptoids into molecular ladders using amines and aldehydes as dynamic covalent reactant pairs and Lewis acidic rare-earth metal triflates as multi-role reagents.

Tags

Keywords: PeptoidsDynamic Covalent Self-assemblySequence-directed AssemblyInformation-directed AssemblyLewis AcidKinetic TrappingCovalent Bond RearrangementFMOC Photolabile Solid Support ResinAutomated Peptide SynthesizerPrimary AmineBromoacetic AcidDICAcetic AnhydrideDMFNMP

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