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JoVE Journal
Immunology and Infection

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In Vivo Augmentation of Gut-Homing Regulatory T Cell Induction
 

In Vivo Augmentation of Gut-Homing Regulatory T Cell Induction

Article DOI: 10.3791/60585-v
January 22nd, 2020

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Summary January 22nd, 2020

Here we present a protocol for in vivo augmentation of gut-homing regulatory T cell induction. In this protocol, dendritic cells are engineered to locally produce high concentrations of the active vitamin D (1,25-dihydroxyvitamin D or 1,25[OH]2D) and the active vitamin A (retinoic acid or RA) de novo.

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