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制备SNS钴（II）针质模型复合物肝酒精脱氢酶

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Chemistry

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JoVE Journal Chemistry

Preparation of SNS Cobalt(II) Pincer Model Complexes of Liver Alcohol Dehydrogenase

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制备SNS钴（II）针质模型复合物肝酒精脱氢酶

DOI:

10.3791/60668-v

•

06:31 min

•

March 19, 2020

•

John R. Miecznikowski, Jerry P. Jasinski, Manpreet Kaur, Sheila C. Bonitatibus, Emilse M. Almanza, Rami M. Kharbouch, Samantha E. Zygmont, Kendra R. Landy

¹Department of Chemistry and Biochemistry,Fairfield University, ²Department of Chemistry,Keene State College

Chapters

00:04Introduction
00:52Chloro-(n³-S,S,N)-[2,6-bis(N-isopropyl-N -methyleneimidazole-2-thione)pyridine]cobalt(II)tetrachlorocobaltate [4] Synthesis
01:42Chloro-(n³-S,S,N)-[2,6-bis(N-isopropyl-N -methyleneimidazole-2-thione)pyridine]cobalt(II)tetrachlorocobaltate [4] Recrystallization
02:34Chloro-(n³-S,S,N)-[2,6-bis(N-isopropyl-N -methylenetriazole-2-thione)pyridine]cobalt(II)tetrachlorocobaltate [5] Synthesis
03:22Chloro-(n³-S,S,N)-[2,6-bis(N-isopropyl-N’-methylenetriazole-2-thione)pyridine]cobalt(II) tetrachlorocobaltate [5] Recrystallization
04:28Results: Representative Liver Alcohol Dehydrogenase Complex Analyses
05:41Conclusion

Summary

Automatic Translation

介绍了肝酒精脱氢酶SNS针质钴（II）模型复合物的制备情况。复合物可以通过用CoCl₂+6H₂O对配体前体进行反应来制备，然后通过允许二苯醚缓慢扩散到含有钴复合物的醋酸酯溶液中来重新结晶。

Tags

Cobalt(II) Pincer Liver Alcohol Dehydrogenase Single Crystal Growth Acetonitrile Reflux Rotary Evaporation Vapor Diffusion 2 6-BIS-N-isopropyl-N’-methyleneimidzole-2-thione-pyridine 2 6-BIS-N-isopropyl-N’-methylenetriazole-2-thione-pyridine Cobalt(II) Chloride Hexahydrate Tetrachlorocobaltate

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