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Brain Death Induction in Mice Using Intra-Arterial Blood Pressure Monitoring and Ventilation via Tracheostomy

Article DOI: 10.3791/60831-v • 05:03 min • April 17th, 2020
April 17th, 2020 •
*1,2,3, *2,4, 5, 2, 1, 1, 6
1Department of Surgery Campus Charité Mitte/Campus Virchow-Klinikum, Charité - Universitätsmedizin Berlin, 2Department of Visceral, Transplant and Thoracic Surgery, Medical University of Innsbruck, 3Charité Clinician Scientist Program, Berlin Institute of Health, 4Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, 5Department of Cardiothoracic Surgery, University Medical Center Regensburg, 6Department of General, Visceral and Vascular Surgery, Charité - Universitätsmedizin Berlin
* These authors contributed equally

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Summary
Automatic Translation

We present a murine model of brain death induction in order to evaluate the influence of its pathophysiological effects on organs as well as on consecutive grafts in the context of solid organ transplantation.

Tags

Brain Death Mice Intra-arterial Blood Pressure Monitoring Ventilation Tracheostomy Solid-organ Transplantation Systemic Inflammatory Response Murine Model Analytical Tools Knockout Models Brain-death Regulation Arterial Catheterization Pedal Reflex Submandibular Glands Neck Muscle Tissue Common Carotid Artery Silk Ligatures Arterial Catheter Preformed Skin Hole Tracheostomy Pretracheal Mus
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